Interesting snippet on Tx resistent depression.

[Arkilogue]

... and you are...?

A wanker who thinks that eating yoghurt will stop me from another suicide attempt.

Your over simplification is unbecoming.

The difference between an unhealthy gut biome and a healthy one is like the difference between a landfill and a rainforest.

You don't change it back by planting one tree. It takes months of dedication and hard work against one's eating habits which are right up there with life and liberty for some people. It grates right against survival mechanisms (food=life) and the sense of self determination (I'll eat what I want) but gut bacteria don't care, gut bacteria don't give a shit. They live, die, thrive or are overrun by disease causing strains based on what you put inside you for them to eat.

If you eat fresh, unprocessed foods, there is more nutrients to feed a greater variety of organisms and less chemicals to make the environment harsher for the weaker varieties. With crap foods full of preservatives, the only things that are going to flourish are harsh scavengers or opportunistic organisms like Candida yeast which can colonize the body, does jump the blood/brain barrier and does affect our behavior in what we crave (sugars and starches to feed the yeast).

While we are on the subject there are a multitude of cordycep fungi that target multiple specific species of insects and drive them to suicidal behavior to aid spore dispersal. Other organisms can affect us and other animals this way like Toxoplasma Gondii which dries rats to suicidal exposure to cats.

[Cyberman]

You've pissed in your own chips with me, I'm afraid. I don't care two wet farts what you think any longer.

[account_inactive]

You've pissed in your own chips with me, I'm afraid. I don't care two wet farts what you think any longer.

Poor chips.

[Minimalist]

Interesting snippet on Tx resistent depression.

  I thought that was Texas resistant depression.

Now I'm bored again.

[Arkilogue]

You've pissed in your own chips with me, I'm afraid. I don't care two wet farts what you think any longer.

What does it matter what you or I think?

http://www.npr.org/sections/health-shots...-your-body

The human body contains about 100 trillion cells, but only maybe one in 10 of those cells is actually — human. The rest are from bacteria, viruses and other microorganisms.

"The human we see in the mirror is made up of more microbes than human," said Lita Proctor of the National Institutes of Health, who's leading the Human Microbiome Project.

"The definition of a human microbiome is all the microbial microbes that live in and on our bodies but also all the genes — all the metabolic capabilities they bring to supporting human health," she said.

These microbes aren't just along for the ride. They're there for a reason. We have a symbiotic relationship with them — we give them a place to live, and they help keep us alive.

"They belong in and on our bodies; they help support our health; they help digest our food and provide many kinds of protective mechanisms for human health," Protor said.

Microbes extract vitamins and other nutrients we need to survive, teach our immune systems how to recognize dangerous invaders and even produce helpful anti-inflammatory compounds and chemicals that fight off other bugs that could make us sick.

"These microbes are part of our evolution. As far as we can tell, they are very important in human health and probably very important in human disease as well," said Martin Blaser of New York University.

These bugs generally don't make us sick. But when we disrupt the delicate ecosystems they carefully construct in different parts of our bodies, scientists think that can make us sick.

"There can be a disturbance in the immune system. There can become some kind of imbalance. And then you can get a microorganism which, under normal circumstances, lives in a benign way and can become a disease-bearing organism," Proctor said.

Taking too many antibiotics, our obsession with cleanliness and even maybe the increase in babies being delivered by Caesarean section may disrupt the normal microbiome, she said.




Woe to Man in egoic pride,
Thinks he is passenger,
When thou art the ride.

[Faith No More]

A New Direction for Treatment-Resistant Depression

http://www.jwatch.org/na42035/2016/08/23...depression

I'm not getting anything from that link. It's just asking me to register. Is this about ketamine? I know that new research is showing that it has potential as a treatment for depression.

Oh, and I just have to say that I'm LMFAO at the idea that you can treat depression with brussel sprouts. Someone alert the APA. It turns out a random dude on the Internet with spurious reasoning skills has figured it all out.

Has anyone else noticed that Arkilogoue is just Little Rik with a better grasp of the English language?

[Faith No More]

A wanker who thinks that eating yoghurt will stop me from another suicide attempt.

What is this "yoghurt" of which you speak? It sounds painful...

[Minimalist]

A wanker who thinks that eating yoghurt will stop me from another suicide attempt.

What is this "yoghurt" of which you speak?  It sounds painful...

May the Schwarz Be With You.

[Arkilogue]

What is this "yoghurt" of which you speak?  It sounds painful...

May the Schwarz Be With You.

Not even with strawberries...

---

Oh, and I just have to say that I'm LMFAO at the idea that you can treat depression with brussel sprouts.  Someone alert the APA.  It turns out a random dude on the Internet with spurious reasoning skills has figured it all out.

Has anyone else noticed that Arkilogoue is just Little Rik with a better grasp of the English language?

Everything I have linked has said "with diet" and I have posted "with change of internal bacterial biome over time."

Your reduction fallacy is getting the better of you.

I'm guessing that last one is a nonplement.

[brewer]

A New Direction for Treatment-Resistant Depression

http://www.jwatch.org/na42035/2016/08/23...depression

I'm not getting anything from that link.  It's just asking me to register.  Is this about ketamine?  I know that new research is showing that it has potential as a treatment for depression.

Apologies, see below.

---

A New Direction for Treatment-Resistant Depression?
Joel Yager, MD reviewing Pan LA et al. Am J Psychiatry 2016 Aug 13.
More than a third of treatment-resistant patients had cerebral folate deficiencies, and all who were treated with folinic acid showed some improvement in depression.


About one third of patients with major depression don't respond to first-line treatments; 15% are resistant to all treatments (treatment-resistant depression [TRD]). After successfully treating TRD in a patient deficient in cerebrospinal fluid (CSF) tetrahydrobiopterin (necessary for biosynthesis of several neurotransmitters) with sapropterin (synthetic form of tetrahydrobiopterin's active isomer), investigators searched for this and other potential metabolic abnormalities in 33 TRD patients.
Patients had failed >3 medication trials (mean age, 26; 76% women; age at onset: ≤17 years, 91%; <10 years, 33%); 85% had comorbid diagnoses, primarily anxiety disorders, post-traumatic stress disorder, or both. Of their first-degree relatives, 82% had histories of depression and 24% had attempted suicide.
Metabolic abnormalities examined in CSF, blood, and urine involved tetrahydrobiopterin, 5-methyltetrahydrofolate (5-MTHF; related to vitamin B9), pyridoxal-5-phosphate (vitamin B6), amino-adipic semialdehyde (biomarker of low cerebral pyridoxine), and major neurotransmitter metabolites (homovanillic acid, 5-hydroxyinoleacetic acid). CSF metabolic abnormalities were detected in 21 patients. Twelve (36%) had cerebral folate deficiency (CFD; low CSF 5-MTHF with normal serum folate); one also had tetrahydrobiopterin deficiency. Nine patients had other abnormalities. CFD patients received 6 weeks of adjunctive folinic acid treatment. All 10 patients with follow-up data showed improved depression scores, which reached normal range in 4. Of 5 patients with elevated suicide scores, 3 showed reductions below threshold.
Comment
This first-ever metabolomics survey specific to the central nervous system in TRD patients lacking neurological symptoms reveals many actionable abnormalities. We need to identify biomarkers not requiring spinal taps and explore how abnormalities might reflect sequelae of depression or other acquired or genetic effects. Although additional study is needed before clinicians begin adopting this adjunctive approach, the authors mention that clinicians wishing to try it in select patients who have failed all other options should use folinic acid (1–2 mg/kg/day), which acts earlier in folate pathways than L-methylfolate.
Editor Disclosures at Time of Publication

• Disclosures for Joel Yager, MD at time of publication Editorial boards Bulletin of the Menninger Clinic; Eating Disorders Review (Editor-in-Chief Emeritus); International Journal of Eating Disorders; UpToDate; FOCUS: The Journal of Lifelong Learning in Psychiatry
  

Citation(s):

1. Pan LA et al. Neurometabolic disorders: Potentially treatable abnormalities in patients with treatment-refractory depression and suicidal behavior. Am J Psychiatry 2016 Aug 13; [e-pub]. (http://dx.doi.org/10.1176/appi.ajp.2016.15111500)
   
   

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