What would you do if you woke up one day to find you were the last person alive?

[Pat Mustard]

I'd load up the car with all my musical instruments, a few hand tools, basic medical supplies, a can opener and a gas siphon and head south to warmer climes.  I'd look for a fairly large city with a good library and some museums, start a garden, and just do stuff -- Read, draw, play music, stargaze, and perhaps keep a diary and chronicle what I was able to find out about the extinction event.  (Originally my plan was to free as many animals as I could, but I see from re-reading the OP that they disappeared, too.)

If all animal life is gone, garden's a waste of tmie. No pollinators.