Trump orders mini nukes

[Anomalocaris]

For fun, read Footfall. They use the Orion system to blast an Iowa-class battleship into space.

In how many pieces?

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Just because hitherto humans have required natural reproduction, normal growth and socialized education and experience to come into being as a cog in The technological society does not mean this will necessarily remain the case very far into the future.

I personally think the technology required to fabricate a flesh and blood human being with pre-encoded biological firmware for the required skills from raw material and genetic Blue print will be perfected long before the technology to allow a sizeable object to attain substantial fractions of the speed of light.

So One possibility for a drone to deliver a Human colony would is for the drone to carry onboard the machinery needed to fabricate human beings, and database of the genes of a sizeable population.  The drone will arrive, mine and process the raw material needed and then fabricate the humans beings required to populate a colony.

If the drone arrives at a system without suitable planets it would be no big loss as there are no living humans aboard.  The drone could simply not proceed to fabricating the colonists, and there would be no casualties resulting from the unfortunate lack of appropriate condition for colonial development.

And you wind up with feral humans.

There will be no humans. The fabrication facilities for making humans won't ever be brought online.