Nicotine has an antagonistic effect on dopamine D2 triggered sexual arousal?

[Ksa]

Just looking if someone has a study that can confirm this:

For a long time I searched a substance that can very quickly disable sexual arousal triggered by an amphetamine stimulation of the dopamine receptors D2 so that I can move from one activity to another easely. With amphetamines, sexual arousal persists for many hours even after intercourse is finished, and even long after 1 half-life elapsed, making it hard to focus on other activities but sex or porn.

Recently I tested nicotine chewing gum in amounts of 4mg when sexual arousal was present and a few minutes after chewing it, it provided a 70% relief of arousal and sexual thoughts for a period of 1 hour. An additional 4mg provided 100% relief of the arousal for the rest of the day.

On another occasion, on a busy day where I had to finish a paper, chewing 4mg of nicotine 30minutes after dosing 15mg dextro-amphetamine XR inhibited sexual arousal symptoms by 50% and over 75% with an additional 4mg after 1 hour, which allowed me to increase the amphetamine dose while remaining productive. This also allowed me to return to previous sexual activities once nicotine was metabolized into cotinine.

I am trying to find a research paper where this antagonistic effect was proven so that I can get more information on the receptors involved.

[pineapplebunnybounce]

I don't know you are being serious.

But, nicotine binds nicotinic acetylcholine receptors, not dopamine. Although the effects may be antagonistic even if the drugs are not directly antagonizing each other. However, I don't think mixing medication (or drugs) without consulting a professional is a good idea. Try looking for helplines in your area that advises people about these things and ask a professional just in case it's unsafe.

[Ksa]

All I could find was this but there's a lot of info that's not specified:

http://www.ncbi.nlm.nih.gov/pubmed/1362898

This suggests a long term effect but the effect I observed was instant, prior to which nicotine was not consumed so it's an instant reaction that required no previous exposure or dependence to nicotine. It feels like the whole thing goes away and I can focus on other things with an equal amount of attention and care.

[Sejanus]

Just looking if someone has a study that can confirm this:

For a long time I searched a substance that can very quickly disable sexual arousal triggered by an amphetamine stimulation of the dopamine receptors D2 so that I can move from one activity to another easely. With amphetamines, sexual arousal persists for many hours even after intercourse is finished, and even long after 1 half-life elapsed, making it hard to focus on other activities but sex or porn.

Recently I tested nicotine chewing gum in amounts of 4mg when sexual arousal was present and a few minutes after chewing it, it provided a 70% relief of arousal and sexual thoughts for a period of 1 hour. An additional 4mg provided 100% relief of the arousal for the rest of the day.

On another occasion, on a busy day where I had to finish a paper, chewing 4mg of nicotine 30minutes after dosing 15mg dextro-amphetamine XR inhibited sexual arousal symptoms by 50% and over 75% with an additional 4mg after 1 hour, which allowed me to increase the amphetamine dose while remaining productive. This also allowed me to return to previous sexual activities once nicotine was metabolized into cotinine.

I am trying to find a research paper where this antagonistic effect was proven so that I can get more information on the receptors involved.

Just wondering how you arrived at those figures...

[Ksa]

Just looking if someone has a study that can confirm this:

For a long time I searched a substance that can very quickly disable sexual arousal triggered by an amphetamine stimulation of the dopamine receptors D2 so that I can move from one activity to another easely. With amphetamines, sexual arousal persists for many hours even after intercourse is finished, and even long after 1 half-life elapsed, making it hard to focus on other activities but sex or porn.

Recently I tested nicotine chewing gum in amounts of 4mg when sexual arousal was present and a few minutes after chewing it, it provided a 70% relief of arousal and sexual thoughts for a period of 1 hour. An additional 4mg provided 100% relief of the arousal for the rest of the day.

On another occasion, on a busy day where I had to finish a paper, chewing 4mg of nicotine 30minutes after dosing 15mg dextro-amphetamine XR inhibited sexual arousal symptoms by 50% and over 75% with an additional 4mg after 1 hour, which allowed me to increase the amphetamine dose while remaining productive. This also allowed me to return to previous sexual activities once nicotine was metabolized into cotinine.

I am trying to find a research paper where this antagonistic effect was proven so that I can get more information on the receptors involved.

Just wondering how you arrived at those figures...

I feel it so I can basically quantify it on a scale from 1 to 10.

[pineapplebunnybounce]

All I could find was this but there's a lot of info that's not specified:

http://www.ncbi.nlm.nih.gov/pubmed/1362898

Publications aren't established science, they're just reports of experiments, they can be wrong. You want to look at textbooks and ask a professional. Really the amount of consideration that has to go into answering the question is beyond what you'll be able to find online. Could you tell me if you're taking any other drugs? Because if you are it could get dangerous because different drugs affect other drugs' doses in your body, so you could be overdosing or underdosing (below therapeutic level) without knowing it. It's just a really bad idea to self medicate.

[Ksa]

All I could find was this but there's a lot of info that's not specified:

http://www.ncbi.nlm.nih.gov/pubmed/1362898

Publications aren't established science, they're just reports of experiments, they can be wrong. You want to look at textbooks and ask a professional. Really the amount of consideration that has to go into answering the question is beyond what you'll be able to find online. Could you tell me if you're taking any other drugs? Because if you are it could get dangerous because different drugs affect other drugs' doses in your body, so you could be overdosing or underdosing (below therapeutic level) without knowing it. It's just a really bad idea to self medicate.

This is a sensitive topic that's easy to derail so let's stay on topic. My question is very simple: 4mg of nicotine removed sexual arousal caused by D2 stimulation: What is the reaction? No reaction mechanism, no congratulations! You know what happened or you don't. Just like in basic biochemistry evaluations. There is no further complication here

But to relieve your worry so that you don't skip a night of sleep over it, I'm an expert, I've been taking these ever since I can remember and I don't recall having adverse effects because I do what's right, I stay away from what is wrong and I do research. I've written Java programs that calculate acetaminophen content at different temperatures, water volumes, accounting for solvent effects and differential calculations on rate of dissolution.

You probably heard stories like Whitney Huston mixing the wrong things and dying on CNN and BBC. Only an idiot would mix what she mixed. Using Flexeril to relieve muscle spasms caused by too much cocaine is idiotic, she should have known what causes those in the first place and just ignore them, instead of adding medication. She should have known that taking Benadryl to sleep after a cocaine binge was idiotic too, if she didn't take cocaine before bed-time she would have had no trouble sleeping. Oh, and let's not forget Xanax because, when all those spasms, palpitations, heart skipping beats and insomnia kick in during comedown, she kind of got scared and got panic attacks because she was clueless what was happening to her body.

It's just natural selection, I wouldn't give it a second thought. Stupid people die and before they do, they pay more taxes, crowd the buses and take pills for headaches or heart burn. I don't take pills for headaches or heart burn: I take non-selective COX-1/2 inhibitors and proton pump inhibitors and I could write a book about each of them. I've seen some posts made by drug users on Bluelight where the terminology was so abstract and profound I needed to do an hour worth of research to go through a few paragraphs, only because I was a chemist and chemical engineer, so I knew what to look for and where. He was only talking in terms of affinity, rate, receptors, activity etc. A layman couldn't even tell that he was talking about drugs. You can't assume just because someone takes a drug that he knows fuckall