All science is materialistic

[Angrboda]

It would certainly put physicalism into doubt here, though there will still be explanations that save physicalism in this case. For example, super advanced aliens that are able to trick our eyes using super advanced technology far beyond our comprehension.

Well, then, let's say that after all of this a god, super being, etc., showed-up glowing with white rage and began torturing any doubting physicalists from the inside out until they, willingly or not, changed their minds and publicly recanted physicalism?

The Duhem–Quine thesis, also called the Duhem–Quine problem, after Pierre Duhem and Willard Van Orman Quine, is that in science it is impossible to experimentally test a scientific hypothesis in isolation, because an empirical test of the hypothesis requires one or more background assumptions (also called auxiliary assumptions or auxiliary hypotheses): the thesis says that unambiguous scientific falsifications are impossible. In recent decades the set of associated assumptions supporting a thesis sometimes is called a bundle of hypotheses. Although a bundle of hypotheses (i.e. a hypothesis and its background assumptions) as a whole can be tested against the empirical world and be falsified if it fails the test, the Duhem–Quine thesis says it is impossible to isolate a single hypothesis in the bundle, a viewpoint called confirmation holism.

Wikipedia || Duhem-Quine thesis