(April 28, 2021 at 10:51 am)FlatAssembler Wrote: I asked that question about inbreeding of viruses on Quora and I received some very complicated response:
https://www.quora.com/Virus-equivalent-o...th-Robison Wrote:Contrary to a couple of answers, recombination between viruses can occur if two closely related viruses co-infect the same cellDo you think that is science or that it is just a theory? If it is science, could you say it in a more layman terminology for me?
Influenza viruses have a segmented RNA genome - each gene on its own RNA molecule. It is nit hard to see that if two such viruses co-infect a cell, the viral packaging equipment cannot tell which parental virus a copy is from. This mechanism accounts for some of the large antigenic “shifts”
Coronaviruses have a single RNA molecule as a genome, but to express many of its genes it must make partial copies of the genome that all share a common 5’ leader. These are crates by a discontinuous replication process - the viral replicase complex pauses and then jumps to another portion of the template and restarts. This jump is not restricted to the same RNA - “template switching” can occur and so recombination can occur
But as Adam Wu neatly pointed out, coronaviruses are haploid so the whole concept of inbreeding doesn’t apply. Any recombined viruses that are lacking critical components will quickly die off.
In layman’s terms, it means you were wrong.
Boru
‘But it does me no injury for my neighbour to say there are twenty gods or no gods. It neither picks my pocket nor breaks my leg.’ - Thomas Jefferson