RE: Of Mice and Men...
March 25, 2016 at 10:15 pm
(This post was last modified: March 25, 2016 at 10:16 pm by Aractus.)
Sure.
But you should know that NTDs develop in the first 3-4 weeks of pregnancy, before women even know they're pregnant
after that termination is the only prevention for a NTD (and it is in fact required for pregnancies affected by anencephaly or encephalocele as the result of carrying the pregnancy to term is certain stillbirth).
So the only women who might be able to benefit are those like the OP who confirm pregnancy around 14 days after ovulation, as it gives them (maybe) six days before the NTD begins to develop. Maybe even less, we actually don't know. The only way to confirm a benefit now is observational studies, because we know that folate deficiency can cause NTDs we can't run experimental studies on humans as it would be unethical. And even if it wasn't unethical it'd be damn-near impossible to recruit participants that have just discovered they're pregnant 14 days after ovulation for your study. Logistically that's near impossible. By the time you found your participants, they'll already be more than 14 days past ovulation and goodbye any chances of getting meaningful results then.
The problem is a lot of literature uses the phrase "periconceptional". This is due to the fact that they've done observational studies (or even the experimental studies done in the early 90's), but there's no way you're going to find women that took a folic acid supplement and stopped the day that conception occurred without even knowing it. So the main problem is that the data cannot be split. But instead, the data can still show you when a woman started taking folic acid. So that's the only meaningful data - is how long before pregnancy did the women take the supplement and what were the results. And IIRC starting two weeks before conception has no benefit whatsoever as it is, let alone starting on the day of conception.
Anyway you want if from literature:
Lane, 2011: "Eighty-nine percent of women consumed supplements but only 31% took folic acid prior to conceiving. Hence, the vast majority are starting too late to prevent neural tube defects (NTDs)."
There are plenty more examples, but I'm not digging them all out.
But you should know that NTDs develop in the first 3-4 weeks of pregnancy, before women even know they're pregnant
after that termination is the only prevention for a NTD (and it is in fact required for pregnancies affected by anencephaly or encephalocele as the result of carrying the pregnancy to term is certain stillbirth).So the only women who might be able to benefit are those like the OP who confirm pregnancy around 14 days after ovulation, as it gives them (maybe) six days before the NTD begins to develop. Maybe even less, we actually don't know. The only way to confirm a benefit now is observational studies, because we know that folate deficiency can cause NTDs we can't run experimental studies on humans as it would be unethical. And even if it wasn't unethical it'd be damn-near impossible to recruit participants that have just discovered they're pregnant 14 days after ovulation for your study. Logistically that's near impossible. By the time you found your participants, they'll already be more than 14 days past ovulation and goodbye any chances of getting meaningful results then.
The problem is a lot of literature uses the phrase "periconceptional". This is due to the fact that they've done observational studies (or even the experimental studies done in the early 90's), but there's no way you're going to find women that took a folic acid supplement and stopped the day that conception occurred without even knowing it. So the main problem is that the data cannot be split. But instead, the data can still show you when a woman started taking folic acid. So that's the only meaningful data - is how long before pregnancy did the women take the supplement and what were the results. And IIRC starting two weeks before conception has no benefit whatsoever as it is, let alone starting on the day of conception.
Anyway you want if from literature:
Lane, 2011: "Eighty-nine percent of women consumed supplements but only 31% took folic acid prior to conceiving. Hence, the vast majority are starting too late to prevent neural tube defects (NTDs)."
There are plenty more examples, but I'm not digging them all out.
For Religion & Health see:[/b][/size] Williams & Sternthal. (2007). Spirituality, religion and health: Evidence and research directions. Med. J. Aust., 186(10), S47-S50. -LINK
The WIN/Gallup End of Year Survey 2013 found the US was perceived to be the greatest threat to world peace by a huge margin, with 24% of respondents fearful of the US followed by: 8% for Pakistan, and 6% for China. This was followed by 5% each for: Afghanistan, Iran, Israel, North Korea. -LINK
"That's disgusting. There were clean athletes out there that have had their whole careers ruined by people like Lance Armstrong who just bended thoughts to fit their circumstances. He didn't look up cheating because he wanted to stop, he wanted to justify what he was doing and to keep that continuing on." - Nicole Cooke
The WIN/Gallup End of Year Survey 2013 found the US was perceived to be the greatest threat to world peace by a huge margin, with 24% of respondents fearful of the US followed by: 8% for Pakistan, and 6% for China. This was followed by 5% each for: Afghanistan, Iran, Israel, North Korea. -LINK
"That's disgusting. There were clean athletes out there that have had their whole careers ruined by people like Lance Armstrong who just bended thoughts to fit their circumstances. He didn't look up cheating because he wanted to stop, he wanted to justify what he was doing and to keep that continuing on." - Nicole Cooke
