I can't say I have any one response.
I isolate a lot, but mostly because I'm shy and a loner and an intermectual.
I drink, post on forums, chat on irc, sleep, listen to music, watch crime shows, collect photos, browse the internet.
I read a lot these days, but usually in prep for a book club. I don't tend to read recreationally, depressed or not, and that gets me down.
I think I'll have a drink. And put on some tunes.