I hope there's little-to-no mention of Shepard or the Reapers. A clean slate. The Mass Effect trilogy are some of my favorite games, I love that they gave something as weird (and horrifying) as Cosmicism such prominence in the story. Best case scenario, we get a story as intelligent as ME1, combat as refined as ME2 and better exploration possibilities than the whole trilogy combined. Worse case scenario, "Oh no, we're trapped in another galaxy!", cue the Mass Effect version of Star Trek Voyager. 
The fact that a believer is happier than a skeptic is no more to the point than that a drunken man is happier than a sober one. ~ George Bernard Shaw
