Can a mistake be so big, that the one who did will never have your respect again?

[Der/die AtheistIn]

Is it possible for someone to make such a big mistake, that you will never respect them again no matter what they do? What if you still appreciate the good about them and still want a relationship with them, but you tell them: "Your mistake was so big that our relationship will have a big ugly hole forever, even if it's alright otherwise.". I personally think that the worst mistakes are the ones who have or could have terrible consequences on others than yourself and innocents as well, could've been easily avoided, the offender had zero or very little impulse to do so as well a lot of obvious reasons not to and the offender had good intentions. If they have bad intentions they either lack empathy or choose to ignore it. Don't get me wrong, I do believe that evil people are worse than well intentioned people, but I find it harder to forgive the ones who have good intentions, because if they fail to do good, they fail to accomplish what they tried to. As far as I know, psychopats didn't choose to be the way they are, so there's that. And if someone has empathy, but refuses to follow it, they might be victims themselves, but even if they aren't, I would have less expectations from them, than from someone with good intentions, at least average intelligence and that hasn't been brainwashed or forced to do and/or believe extremely stupid and/or distructive things.