Interesting thread.
I am not afraid to divulge that I suffer from two severe mental illnesses: melancholic depression and severe OCD. Without my amazing medication (sertraline and mirtazapine), I suffer from psychomotor retardation, feelings of intense guilt, extreme suicidal ideation, extreme anhedonia, extreme insomnia and my obsessions/compulsions are absolutely terrible. Current evidence suggests that melancholic depression is caused by a defective monoamine system; that is, a major imbalance of the three main monoamine neurotransmitters serotonin, norepinephrine and dopamine. OCD is primarily caused by serotonin dysfunction. Sertraline is a selective serotonin reuptake inhibitor as well as being a mild dopamine reuptake inhibitor. Mirtazapine increases norepinephrine transmission indirectly by antagonising the Alpha-2 adrenergic receptor. Therefore, I get a boost in all three of these monoamines.
Creed, are you willing to divulge if you are on any medication? I find sertraline and mirtazapine to be an outstanding combination for these terrible illnesses.
I am not afraid to divulge that I suffer from two severe mental illnesses: melancholic depression and severe OCD. Without my amazing medication (sertraline and mirtazapine), I suffer from psychomotor retardation, feelings of intense guilt, extreme suicidal ideation, extreme anhedonia, extreme insomnia and my obsessions/compulsions are absolutely terrible. Current evidence suggests that melancholic depression is caused by a defective monoamine system; that is, a major imbalance of the three main monoamine neurotransmitters serotonin, norepinephrine and dopamine. OCD is primarily caused by serotonin dysfunction. Sertraline is a selective serotonin reuptake inhibitor as well as being a mild dopamine reuptake inhibitor. Mirtazapine increases norepinephrine transmission indirectly by antagonising the Alpha-2 adrenergic receptor. Therefore, I get a boost in all three of these monoamines.
Creed, are you willing to divulge if you are on any medication? I find sertraline and mirtazapine to be an outstanding combination for these terrible illnesses.
