Nicotine has an antagonistic effect on dopamine D2 triggered sexual arousal?
January 7, 2014 at 5:38 pm
(This post was last modified: January 7, 2014 at 5:45 pm by Ksa.)
Just looking if someone has a study that can confirm this:
For a long time I searched a substance that can very quickly disable sexual arousal triggered by an amphetamine stimulation of the dopamine receptors D2 so that I can move from one activity to another easely. With amphetamines, sexual arousal persists for many hours even after intercourse is finished, and even long after 1 half-life elapsed, making it hard to focus on other activities but sex or porn.
Recently I tested nicotine chewing gum in amounts of 4mg when sexual arousal was present and a few minutes after chewing it, it provided a 70% relief of arousal and sexual thoughts for a period of 1 hour. An additional 4mg provided 100% relief of the arousal for the rest of the day.
On another occasion, on a busy day where I had to finish a paper, chewing 4mg of nicotine 30minutes after dosing 15mg dextro-amphetamine XR inhibited sexual arousal symptoms by 50% and over 75% with an additional 4mg after 1 hour, which allowed me to increase the amphetamine dose while remaining productive. This also allowed me to return to previous sexual activities once nicotine was metabolized into cotinine.
I am trying to find a research paper where this antagonistic effect was proven so that I can get more information on the receptors involved.
For a long time I searched a substance that can very quickly disable sexual arousal triggered by an amphetamine stimulation of the dopamine receptors D2 so that I can move from one activity to another easely. With amphetamines, sexual arousal persists for many hours even after intercourse is finished, and even long after 1 half-life elapsed, making it hard to focus on other activities but sex or porn.
Recently I tested nicotine chewing gum in amounts of 4mg when sexual arousal was present and a few minutes after chewing it, it provided a 70% relief of arousal and sexual thoughts for a period of 1 hour. An additional 4mg provided 100% relief of the arousal for the rest of the day.
On another occasion, on a busy day where I had to finish a paper, chewing 4mg of nicotine 30minutes after dosing 15mg dextro-amphetamine XR inhibited sexual arousal symptoms by 50% and over 75% with an additional 4mg after 1 hour, which allowed me to increase the amphetamine dose while remaining productive. This also allowed me to return to previous sexual activities once nicotine was metabolized into cotinine.
I am trying to find a research paper where this antagonistic effect was proven so that I can get more information on the receptors involved.