Any fule kno it was Papa Doc Duvalier who put a curse on him, combined with the fact that he was presidented in a year divisible by twenty (triggering an older but oddly specific curse). No need for conspiracies or Cold War intrigue - poor bastard never stood a chance. Quite frankly, Oswald probably did him a favour.
At the age of five, Skagra decided emphatically that God did not exist. This revelation tends to make most people in the universe who have it react in one of two ways - with relief or with despair. Only Skagra responded to it by thinking, 'Wait a second. That means there's a situation vacant.'