Anything that affects the physical world is squarely in the domain of science, by direct definition. Anything that doesn't affect the physical world can safely be ignored as irrelevant and, to all intents and purposes, nonexistent.
At the age of five, Skagra decided emphatically that God did not exist. This revelation tends to make most people in the universe who have it react in one of two ways - with relief or with despair. Only Skagra responded to it by thinking, 'Wait a second. That means there's a situation vacant.'